Coalescipede

These shadowy spiders are found within the Shaded Citadel. Small spiders are afraid of light and will flee from the slugcat when carrying a light source. However, large numbers of spiders can aggregate, making them less fearful of light and consequently more hostile. Smaller clumps of spiders are typically not dangerous, but will kill and snatch lanternmice from slugcat. Medium sized clumps can potentially be dangerous to the slugcat. Large aggregations of spiders form what looks to be a "Spider-pede", which will attack the slugcat irrespective of a light source.

Spider clumps can be broken up by throwing items at them (eg. spears or rocks), causing them to disperse back to individual, small spiders and thus reducing their hostility. The light generated from throwing a flashbang will typically kill all spiders in a single room.

Even though lanternmice generate their own light, individual lanternmice are unable to fend off even small spider clumps.

Trivia

 * The number of spiders needed to kill you depends on their size: 3 when large, 6 to 7 when medium.
 * Tiny spiders aren't harmful.
 * Scavengers in the Shaded Citadel have lightstones with them. This appears to indicate that they are aware that spiders fear bright light.
 * A spider-pede formation will snatch lanternmice from slugcat.